TNKS-IN-3

TNKS-IN-3 (Compound 6) is a TNKS2 inhibitor (Ki: 8.5 nM) . TNKS-IN-3 has good activity (IC50: 71 nM) and can effectively inhibit the WNT/β-catenin signaling pathway. TNKS-IN-3 can be used in the research of diseases such as cancer and fibrosis[1].

C30H27N5O4S

553.63

O=C(NC1=CC=CC=C1OC)C2=CC=C(NC(N(CCC(N3)=NC4=C(C=CC=C4)C3=O)CC5=CC=CS5)=O)C=C2

PARP

TNKS2/PARP5B

Room temperature