TNKS1/2-IN-2 [CAS 1498300-35-8]

TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC50 values of 4 nM and 63 nM against TNK1 and TNK2 in the enzymatic assay, respectively. TNKS1/2-IN-2 inhibits proliferation of A549 and H292 cell lines with IC50 values of 39.5 nM and 12.8 nM, respectively. TNKS1/2-IN-2 can be used for the research of cancer[1].

[1498300-35-8]

C26H24F3N3O4

499.48

O=C(N(C1=O)C[C@@H]2CC[C@H](CC2)C(O)=O)C(C(N1CC3=C(C(C(F)(F)F)=CC=C3)C#N)=CC=C4)=C4C

PARP; TNK1

10 mM in DMSO

Room temperature