TNP-ATP (tetrasodium)
TNP-ATP (tetrasodium)
SKU:QM-0006498
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Product Details
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Description
TNP-ATP is an antagonist of purinergic P2Y1, P2X3, and P2X2/3 receptors (IC50 = 6, 0.9, and 7 nM, respectively, in HEK293 cells expressing human receptors) . TNP-ATP reduces acetate-induced calcium flux in 1321N1 cells expressing P2X3 and P2X2/3 receptors (IC50 = 100 and 62 nM, respectively) . TNP-ATP dose-dependently attenuates acetate-induced abdominal contractions in a mouse visceral pain model (ED50 = 6.35 µmol/kg) [1][2].
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Molecular Formula
C16H13N8Na4O19P3
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Molecular Weight
806.2
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Smiles
O=[N](C(C1(C([N](=O)=O)=C2)O[C@]([C@@](N3C4=NC=NC(N)=C4N=C3)([H])O[C@@H]5CO[P](O[P](O[P](O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)([H])[C@]5([H])O1)=CC2[N](=O)=O)=O
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Target
P2X Receptor; P2Y Receptor
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Isoform
P2X3 Receptor; P2Y1 Receptor
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Shipping Conditions
Room temperature
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TNP-ATP (tetrasodium)
TNP-ATP (tetrasodium) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.