TO-1187 (TFA)

TO-1187 TFA is a selective HDAC6 PROTAC degrader (DC50: 5.81 nM). TO-1187 TFA promotes the ubiquitination and degradation of HDAC6 and can be used in the study of hematological malignancies and solid tumors (Pink: HDAC6 ligand ; Blue: CRBN ligase ligand (HY-41547) ; Black: linker (HY-140212) ).

C36H36F3N9O9

795.72

O=C(C1=CC=C(C=C1)CN(CC2=CN=CC=C2)CC3=CN(N=N3)CCOCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)NO.OC(C(F)(F)F)=O

HDAC; PROTACs

Cereblon; HDAC6

98.41

DMSO : 100 mg/mL (ultrasonic)

4°C (Powder, stored under nitrogen)

Room Temperature