Tolcapone 3-β-D-glucuronide [CAS 204853-33-8]
Tolcapone 3-β-D-glucuronide [CAS 204853-33-8]
SKU:QM-0131565
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Product Details
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Description
Tolcapone 3-β-D-glucuronide (Ro 61-1448) is an O-methyl metabolite of Tolcapone and is pharmacologically inactive. Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC50of 773 nM. Tolcapone can inhibits α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma[1][2][3][4][5].
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CAS Number
[204853-33-8]
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Molecular Formula
C20H19NO11
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Molecular Weight
449.36
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Smiles
O[C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@H]1OC2=CC(C(C3=CC=C(C=C3)C)=O)=CC([N+]([O-])=O)=C2O)C(O)=O
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Target
Amyloid-β; Apoptosis; COMT; Drug Metabolite; Reactive Oxygen Species (ROS)
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Shipping Conditions
Room temperature
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Tolcapone 3-β-D-glucuronide [CAS 204853-33-8]
Tolcapone 3-β-D-glucuronide is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.