Tolcapone-d7

Tolcapone-d7 (Ro 40-7592-d7) is the deuterium labeled Tolcapone. Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC50of 773 nM. Tolcapone can inhibits α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma[1][2][3][4].

C14H4D7NO5

280.28

O=C(C1=CC(O)=C(O)C([N+]([O-])=O)=C1)C2=C([2H])C([2H])=C(C([2H])([2H])[2H])C([2H])=C2[2H]

Amyloid-β; Apoptosis; COMT; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)

10 mM in DMSO

Room temperature