TP-050 [CAS 3085030-47-0]

TP-050, a chemical probe, is a potent, orally active and selective NMDAR agonist with an EC50 value of 0.51 μM and 9.6 μM for GluN2A and GluN2D, respecticely. TP-050 can cross the blood-brain barrier (BBB) . TP-050 induces hippocampal long-term (LPT) potentiation enhancemen and enhances neuronal signal transmission[1].

[3085030-47-0]

C16H15ClF2N6O

380.78

CC1=CN(C(C2=CC(CN3N=C(C=C3Cl)C(F)F)=NN12)=O)[C@@H](CC#N)C

IGluR

10 mM in DMSO

Room temperature