TPA-dT

TPA-dT is a thymidine analog with a tris[ (2-pyridyl) methyl]amine (TPA) group. TPA-dT can be used to modify siRNAs. The TPA-modified siRNAs remain functionally inactive and is incapable of silencing gene expression until the TPA moiety is removed upon exposure to Cu (I) [1].

C29H32N6O5

544.6

O[C@H]1C[C@H](N2C(N=C(OCC3=CC=CC(CN(CC4=NC=CC=C4)CC5=NC=CC=C5)=N3)C(C)=C2)=O)O[C@@H]1CO

Small Interfering RNA (siRNA)

10 mM in DMSO

Room temperature