TPAPyN

TPAPyN is a nitroreductase (NTR) -responsive type I photosensitizer. TPAPyN facilitates the imaging of hypoxic cancer cells and image-guided photodynamic therapy (PDT) . TPAPyN does not emit fluorescence in the aqueous environment, but restores when NTR cleaves the nitrofuran quencher with aggregation-induced emission. TPAPyN can be used as a fluorescent probe for specific imaging of hypoxic cancer[1].

C32H28BrN3O5

614.49

COC1=CC=C(N(C2=CC=C(OC)C=C2)C3=CC=C(/C=C/C4=CC=[N+](CC5=CC=C([N+]([O-])=O)O5)C=C4)C=C3)C=C1.[Br-]

Photosensitizer

Room temperature