TPB15 [CAS 2170347-69-8]

TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1) . TPB15 shows good anti-tumor activity with low toxicity[1].

[2170347-69-8]

C18H9Cl4N5O

453.11

O=C(C1=C(N=C(C=C1)Cl)Cl)NC2=CC(C3=NN=C4C(Cl)=CC=CN43)=C(C=C2)Cl

Apoptosis; Gli; Hedgehog; Smo

10 mM in DMSO

Room temperature