TPE-MI [CAS 1245606-71-6]

TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm) . TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum [1][2].

[1245606-71-6]

C31H23NO2

441.52

O=C(C=C1)N(C2=CC=C(/C(C3=CC=CC=C3)=C(C4=CC=C(C)C=C4)/C5=CC=CC=C5)C=C2)C1=O

Huntingtin; Parasite

Plasmodium

98.93

DMSO : 8.57 mg/mL (ultrasonic; warming; heat to 60°C)

4°C (Powder, protect from light)

Room Temperature

H302, H315, H319

H302, H315, H319