TPH1-IN-1 [CAS 3040015-86-6]

TPH1-IN-1 (compound 40) is a xanthine derivative and an inhibitor of tryptophan hydroxylase TPH1 (IC50: 110.1 nM) . TPH1-IN-1 has good in vitro activity and liver microsome stability, and effectively inhibits adipocyte differentiation of T3-L1 cells[1].

[3040015-86-6]

C21H18N6O4S

450.47

OC1=CC=C(C(CN2C(C(NC(N3CC)=O)=O)=C3N=C2CC4=CN5C(SC=C5)=N4)=O)C=C1

Tryptophan Hydroxylase

10 mM in DMSO

Room temperature