TR-213 [CAS 2980502-40-5]

TR-213 is a potent molecular glue degrader that targets Cyclin K (CDK) . TR-213 induces 91% and 56% decrease in CDK12 and Cyclin at 1 μM. TR-213 can inhibit RNA polymerase II activity and regulates alternative polyadenylation (APA) activity. TR-213 can be used for the research of cancer[1].

[2980502-40-5]

C22H20N4O3

388.42

N#CC1=CC=CC(C2=CCN(CC2)C3=NC(C4=CC(OC)=C(C=C4N3)OC)=O)=C1

CDK; DNA/RNA Synthesis; Molecular Glues

Room temperature