TRAP1-IN-1 [CAS 3031102-94-7]

TRAP1-IN-1 (compound 35) is a potent and selective inhibitor of TRAP1, a mitochondrial isoform of Hsp90. TRAP1-IN-1 has >250-fold TRAP1 selectivity over Grp94, and disrupts TRAP1 tetramer stability, induces TRAP1 client protein degradation. TRAP1-IN-1 also inhibits mitochondrial complex I of oxidative phosphorylation OXPHOS, disrupts the mitochondrial membrane potential, and enhances glycolysis metabolism[1].

[3031102-94-7]

C45H39F7N2O4P2

866.74

O=C(C1=C(O)C=CC(C(N2CC(C(F)=CC=C3)=C3C2)=O)=C1)N(C4)CC5=C4C=CC(OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)=C5.F[P-](F)(F)(F)(F)F

HSP; Mitochondrial Metabolism

96.03

DMSO : 200 mg/mL (ultrasonic)

4°C (Powder, sealed storage, away from moisture)

Room Temperature