α-Triglycidyl isocyanurate [CAS 59653-73-5]

α-Triglycidyl isocyanurate (Teroxirone) is an antitumor compound with activity to inhibit DNA replication. α-Triglycidyl isocyanurate exerts its anticancer effect by alkylating and cross-linking DNA. α-Triglycidyl isocyanurate is relatively stable in fresh human plasma and whole blood, showing good biocompatibility. The metabolism of α-Triglycidyl isocyanurate mainly occurs in rat liver and is metabolized through an NADPH-independent pathway. The cytotoxicity of α-Triglycidyl isocyanurate can be partially restored under specific conditions, suggesting the complexity of its metabolic pathway[1].

[59653-73-5]

C12H15N3O6

297.26

O=C(N(C(N(C1=O)C[C@H]2CO2)=O)C[C@@H]3CO3)N1C[C@@H]4CO4

Endogenous Metabolite

Room temperature