Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA) . Trimetazidine is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor[1][2][3][4].
CAS Number
[5011-34-7]
Molecular Formula
C14H22N2O3
Molecular Weight
266.34
Smiles
COC1=CC=C(CN2CCNCC2)C(OC)=C1OC
Target
Autophagy
Purity
99.84
Solubility
DMSO : 116.67 mg/mL (ultrasonic; warming; heat to 60°C)
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)