TRK-IN-31

TRK-IN-31 is an orally active TRK inhibitor with an IC50 of 1.8 nM. TRK-IN-31 has superior antiproliferative activity in the Ba/F3-MPRIP-TRKAG667C cells, and potently inhibits TRK kinase activity with high selectivity. TRK-IN-31 significantly inhibits tumor growth in Ba/F3-MPRIP-TRKAG667C subcutaneous tumor mice model[1].

C30H29F2N5O4

561.58

FC1=CC=C(C=C1[C@@H]2N(C3=CNC(C(C(NC4=CC5=C(C=C4)OC(C(N6CCN(CC6)C)=O)=C5)=O)=C3)=O)CCC2)F

Trk Receptor

Trk

Room temperature