Trk-IN-7 [CAS 2383011-61-6]

Trk-IN-7 (compound I-6) is a potent TRK inhibitor with IC50s of ranging from 0.25-10 nM for TRKA, TRKB and TRKC, respectively. Trk-IN-7 shows inhibition against EML4-ALK (IC50IC50=5-50 nM) [1].

[2383011-61-6]

C18H17FN6O2

368.36

FC1=CN=C(O[C@H]2C[C@H](C2)NC3=O)C([C@H](NC4=NC5=C3C=NN5C=C4)C)=C1

Trk Receptor

TrkA; TrkB; TrkC

10 mM in DMSO

Room temperature