TrxR-IN-3 [CAS 2445565-58-0]

TrxR-IN-3 (Compound 2c) is a potent inhibitor of TrxR. TrxR-IN-3 exhibits potent antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and resulted in marked apoptosis by regulating apoptosis-related proteins expressed in the breast cancer cells. TrxR-IN-3 also triggers the formation of autophagosomes and autolysosomes by promoting the expression of LC3-II and Beclin-1 and diminishing the expression of LC3-I and p62 proteins[1].

[2445565-58-0]

C14H11F3O2

268.23

O=C1C=CCC/C1=C\C2=CC=C(OC(F)(F)F)C=C2

TrxR

10 mM in DMSO

Room temperature