TrxR1-IN-2

TrxR1-IN-2 (Compound 6a) is a TrxR1 inhibitor that covalently binds to the Cys475 and Sec498 sites of TrxR1, thereby inhibiting TrxR1 activity and leading to redox homeostasis disruption, which triggers apoptosis and ferroptosis[1].

C19H23NO6

361.39

O=C1O[C@@H]2C=C1C[C@H]3[C@@H](C(C(O3)=O)=C)[C@H](OC(NCCC)=O)/C=C(C)/C2

Apoptosis; Ferroptosis; TrxR

Room temperature