TTBK1-IN-2 [CAS 2765453-51-6]

TTBK1-IN-2 (compound 29) is a potent Tau-Tubulin kinase (TTBK1) inhibitor with IC50s of 0.24 and 4.22 µM, respectively. TTBK1-IN-2 reveals good brain penetration in vivo and is able to reduce TDP-43 phosphorylation not only in cell cultures but also in the spinal cord of transgenic TDP-43 mice[1].

[2765453-51-6]

C18H13ClN4O

336.78

ClC1=CC=C(OC2=CC=C(C=C2)NC3=C4C(NC=C4)=NC=N3)C=C1

Tau Protein

99.91

DMSO : 50 mg/mL (ultrasonic; adjust pH to 2 with HCl)

4°C (Powder, protect from light)

Room Temperature

H302, H315, H319

H302, H315, H319