TTK21 [CAS 709676-56-2]

TTK21 is an activator of the histone acetyltransferases CBP/p300. TTK21 passes the blood–brain barrier, induces no toxicity, and reaches different parts of the brain when conjugated to glucose-based carbon nanosphere (CSP) . TTK21 has beneficial implications for the brain functions of neurogenesis and long-term memory[1].CSP-TTK21 can ameliorate Aβ-impaired long-term potentiation (LTP) . CSP-TTK21 may enhance the transcription of genes that promote synaptic health and cognitive function[2]. CSP-TTK21 is orally effective and leads to improvements in motor functions, histone acetylation dynamics in a spinal injury rat model[3].

[709676-56-2]

C17H15ClF3NO2

357.75

ClC1=CC=C(C=C1C(F)(F)F)NC(C2=CC=CC=C2OCCC)=O

Histone Acetyltransferase

CBP/p300

99.39

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H315, H319

H315, H319