Tubulysin F [CAS 368870-67-1]

Tubulysin F is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin) . Tubulysin F can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin F displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin F inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis[1][2].

[368870-67-1]

C41H61N5O9S

800.02

O=C([C@@H]1N(CCCC1)C)N[C@]([C@@H](C)CC)([H])C(N(COC(CC)=O)[C@@H](C(C)C)C[C@H](C2=NC(C(N[C@H](C[C@H](C)C(O)=O)CC3=CC=CC=C3)=O)=CS2)OC(C)=O)=O

ADC Payload; Microtubule/Tubulin

10 mM in DMSO

Room temperature