TWIK-1/TREK-1-IN-1 [CAS 1440532-30-8]

TWIK-1/TREK-1-IN-1 (compound 2a) is an inhibitor of the TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.36 μM and 14.6 μM, respectively, and has antidepressant-like effects[1].

[1440532-30-8]

C21H24F3NO3

395.42

OC(CC1)(C2=CC=CC=C2)CCN1C[C@@H](O)COC3=CC=C(C(F)(F)F)C=C3

Potassium Channel

10 mM in DMSO

Room temperature