TYK2-IN-11 [CAS 2757009-40-6]

TYK2-IN-11 (Compound 5B) is a selective Tyk-2 inhibitor with IC50s of 0.016 and 0.31 nM for TYK2-JH2 and JAK1-JH2, respectively. TYK2-IN-11 can be used for the research of inflammatory or autoimmune disease[1].

[2757009-40-6]

C18H17N5O3S

383.42

O=C(C)NC1=CC(NC2=CC=CC(S(=O)(C)=O)=N2)=C(C3=NC=CC=C3)C=N1

JAK

10 mM in DMSO

Room temperature