The UBE2V1 protein does not have intrinsic ubiquitin ligase activity and can cooperate with UBE2N to synthesize non-canonical polyubiquitin chains linked through Lys-63. This type of polyubiquitination activates IKK and mediates NF-kappa-B activation, thereby affecting transcriptional activation, cell cycle progression, and DNA repair. UB2V1 Protein, Human (sf9, His, Strep) is the recombinant human-derived UB2V1 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.
