UBP141 [CAS 344768-30-5]

UBP141 is a GluN2C/2D (NR2C/2D) -preferring receptor antagonist, with Kds of 2.8, 4.2, 14.2, and 19.3 μM for NMDA receptor subtypes: GluN2C, 2D, 2A, and 2B, respectively. UBP141 can induce potent motor impairment in WT mice[1][2].

[344768-30-5]

C21H18N2O5

378.38

O=C(O)[C@@H]1N(CCN[C@@H]1C(O)=O)C(C2=CC=C3C=CC4=CC=CC=C4C3=C2)=O

IGluR

10 mM in DMSO

Room temperature