UCB9386

UCB9386 is the selective and brain penetrant inhibitor for Nuak1 with a pIC50 of 10.1. UCB9386 inhibits Nuak2 and Kak2 with an inhibition rate of ca. 50% at 10 nM[1].

C27H26N8O

478.55

C[C@H](C1=CC=CC=C1)N(C(C(N2CC3(CN(C)C3)C2)=N4)=O)C5=C4C=NC(C6=CN=C7C=CC=NN76)=C5

AMPK; JAK

99.89

DMSO : 83.33 mg/mL (ultrasonic; adjust pH to 7 with 1 M HCL)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature