UCM-13369 [CAS 2921944-77-4]

UCM-13369 (Compound 4b) is a NPM1 inhibitor. UCM-13369 downregulates the pathway associated with mutant NPM1 C+, and specifically recognizes the C-end DNA-binding domain of NPM1 C+. UCM-13369 induces apoptosis in AML cell lines and primary cells, that can be used for the research of AML[1].

[2921944-77-4]

C25H31N3O

389.53

N[C@@H]([C@@H]1CCNCC2CC2)[C@@H](C3=CC=C(OC)C=C3)CC4=C1C5=C(N4)C=CC=C5

Apoptosis

10 mM in DMSO

Room temperature