UDM-001651 [CAS 1477497-01-0]

UDM-001651 is a potent, selective, and orally bioavailable protease-activated receptor 4 (PAR4) antagonist (IC50=4 nM; Kd=1.4 nM) . UDM-001651 shows antiplatelet potency (IC50=25 nM) in a γ-thrombin-induced platelet-rich plasma aggregation assay (γ-Thr PRP) [1].

[1477497-01-0]

C28H23N3O5S

513.56

COC1=CC(OCC2=CC=CC(OCC3=CC=CC=C3)=C2)=C4C=C(C5=CN6C(SC(OC)=N6)=N5)OC4=C1

Protease Activated Receptor (PAR)

PAR4

10 mM in DMSO

Room temperature