Umbelopsisin A

Umbelopsisin A is a GABAA and GABAB non-selective agonist. Umbelopsisin A activates the GABAergic pathway, including notch signaling and fatty acid metabolism. Umbelopsisin A shows dual neuroprotection against glutamate excitotoxicity in vitro (reducing ROS and cell death) and in vivo. Umbelopsisin A can be used for the study of glaucoma and broader neurodegenerative disease applications[1].

C21H19NO5

365.38

CC1=C(O)C(C)=C(C)C([C@@]2(C3=CNC4=CC=CC=C43)C(OC)=O)=C1OC2=O

GABA Receptor; Reactive Oxygen Species (ROS)

Room temperature