UNC-2170 (maleate) [CAS 2173992-60-2]

UNC-2170 maleate is the maleate salt form of UNC-2170. UNC-2170 maleate is a selective inhibitor for the methyl-lysine binding protein 53BP1, with IC50 of 29 µM and Kd of 22 µM. UNC-2170 maleate shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB).

[2173992-60-2]

C18H25BrN2O5

429.31

O=C(NCCCNC(C)(C)C)C1=CC=CC(Br)=C1.O=C(O)/C=C/C(O)=O

DNA/RNA Synthesis

Room temperature

H302-H312-H332

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501