UNC8153 [CAS 2929304-60-7]

UNC8153 is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2) -targeted degrader with a Kd of 24 nM. UNC8153 reduces the cellular levels of both NSD2 protein (DC50 in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark. UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2[1].

[2929304-60-7]

C33H37N5O5

583.68

O=C(C1=CC=C2NC(COC2=C1)=O)N(CC3=CC=C(C(NC4=CC=C(C(NCCCCCCN)=O)C=C4)=O)C=C3)C5CC5

Histone Methyltransferase

99.13

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature