V116517 [CAS 1073616-61-1]

V116517 is a potent, orally active transient receptor potential vanilloid (TRPV1) antagonist. V116517 shows potent activity in inhibiting both capsaicin (CAP) - and acid (pH 5) -induced currents in rat DRG neurons expressing native TRPV (IC50=423.2 nM for CAP; IC50=180.3 nM for acid) . V116517 can be used for the research of pain[1].

[1073616-61-1]

C19H18ClF3N4O3

442.82

O=C(N1CC=C(C2=NC=C([C@H](O)CO)C=C2Cl)CC1)NC3=NC=C(C(F)(F)F)C=C3

TRP Channel

TRPV1

10 mM in DMSO

Room temperature