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Vandetanib (trifluoroacetate) [CAS 338992-53-3]
Vandetanib (trifluoroacetate) [CAS 338992-53-3]
SKU:QM-0000224
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Product Details
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Description
Vandetanib trifluoroacetate (D6474 trifluoroacetate) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM) . Vandetanib trifluoroacetate also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM) [1].
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CAS Number
[338992-53-3]
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Molecular Formula
C24H25BrF4N4O4
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Molecular Weight
589.38
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Smiles
FC1=CC(Br)=CC=C1NC2=NC=NC3=CC(OCC4CCN(CC4)C)=C(C=C23)OC.O=C(O)C(F)(F)F
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Target
Apoptosis; Autophagy; VEGFR
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Isoform
VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Vandetanib (trifluoroacetate) [CAS 338992-53-3]
Vandetanib (trifluoroacetate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.