Vardenafil [CAS 224785-90-4]

Vardenafil is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM, while IC50s are >1000 nM for PDE3 and PDE4[1]. Vardenafil competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels[2]. Vardenafil can be used for the research of erectile dysfunction, hepatitis, diabetes[1]-[6].

[224785-90-4]

C23H32N6O4S

488.6

CCCC1=NC(C)=C2N1N=C(C(C=C(S(=O)(N3CCN(CC)CC3)=O)C=C4)=C4OCC)NC2=O

Endogenous Metabolite; Phosphodiesterase (PDE)

PDE1; PDE3; PDE4; PDE5; PDE6

99.81

DMSO : 25 mg/mL (ultrasonic)

4°C (Powder, sealed storage, away from moisture and light)

Room Temperature

H301, H373, H410

H301, H373, H410