VEC6 [CAS 3431-16-1]

VEC6 (NSC 11435) is an inhibitor of VEZF1–DNA interaction and has the activity to recapitulate RhoB loss in ischemic retinopathy. VEC6 reduces pathological angiogenesis and promotes lymphangiogenesis. VEC6 plays a unique role in angiogenesis and lymphangiogenesis by regulating the expression of different sets of genes in endothelial cells. VEC6 has an inhibitory effect on VEZF1-mediated transcriptional activity, thereby affecting the proliferation and sprouting of endothelial cells[1].

[3431-16-1]

C14H20N4

244.34

CN(C(CCC1)C2)C1CN2/N=N/C3=CC=CC=C3

Endogenous Metabolite

Room temperature