Velpatasvir [CAS 1377049-84-7]

Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 2.16 μM[2].

[1377049-84-7]

C49H54N8O8

883

O=C(N([C@H]1C)[C@@H](CC1)C2=NC3=C(C(C=C(OCC4=CC(C5=CN=C([C@H](C[C@H](COC)C6)N6C([C@@H](C7=CC=CC=C7)NC(OC)=O)=O)N5)=CC=C84)C8=C9)=C9C=C3)N2)[C@H](C(C)C)NC(OC)=O

HCV; SARS-CoV

10mM

99.83

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H315, H319, H320

H315, H319, H320