Vismodegib-d7 [CAS 2733145-73-6]

Vismodegib-d7 is deuterium labeled Vismodegib. Vismodegib (GDC-0449) is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively[1][2].

[2733145-73-6]

C19H7D7Cl2N2O3S

428.34

ClC1=C(C([2H])=C(C([2H])=C1C2=C(C([2H])=C(C([2H])=N2)[2H])[2H])NC(C3=C(C=C(C=C3)S(C)(=O)=O)Cl)=O)[2H]

Isotope-Labeled Compounds

Room temperature