Vm24-toxin (TFA)

Vm24-toxin (Vaejovis mexicanus peptide 24) TFA, a 36-residue peptide, is a potent and selective Kv1.3 blocker with a Kd of ~3 pM in lymphocytes. Vm24-toxin TFA shows >1500-fold affinity for Kv1.3 over other assayed potassium channels. Vm24-toxin TFA folds into a distorted cystine-stabilized α/β motif consisting of a single-turn α-helix and a three-stranded antiparallel β-sheet, stabilized by four disulfide bridges. Vm24-toxin TFA attenuates the CD4+ effector memory T cell response to T cell receptor (TCR) stimulation[1][2].

C157H253N51O45S9.xC2HF3O2

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Potassium Channel

Voltage-gated potassium channel

97.86

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Blue Ice