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VU0422288 [CAS 1630936-95-6]

VU0422288 [CAS 1630936-95-6]

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QM-0136751-01

£129.63 GBP
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Product Details

  • Description

    VU0422288 (ML396) is a positive allosteric modulator of group III mGluRs. VU0422288 inhibits mGluRs with EC50s of 125 nM, 146 nM, and 108 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice[1][2].

  • CAS Number

    [1630936-95-6]

  • Molecular Formula

    C17H11Cl2N3O2

  • Molecular Weight

    360.19

  • Smiles

    ClC(C=C(NC(C1=CC=CC=N1)=O)C=C2)=C2OC3=CC=C(Cl)C=N3

  • Target

    MGluR

  • Isoform

    MGluR4; mGluR7; mGluR8

  • Purity

    99.94

  • Solubility

    DMSO : 25 mg/mL (ultrasonic)

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature

  • Hazard Statement

    H302, H319

  • Precautions

    H302, H319
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Variant Variant total Quantity Price Variant total
5 mgQM-0136751-01
5 mgQM-0136751-01
£129.63/ea		 £0.00
£129.63/ea £0.00
10 mM - 1 mLQM-0136751-02
10 mM - 1 mLQM-0136751-02
£139.75/ea		 £0.00
£139.75/ea £0.00
10 mgQM-0136751-03
10 mgQM-0136751-03
£238.32/ea		 £0.00
£238.32/ea £0.00
25 mgQM-0136751-04
25 mgQM-0136751-04
£426.65/ea		 £0.00
£426.65/ea £0.00
50 mgQM-0136751-05
50 mgQM-0136751-05
£652.64/ea		 £0.00
£652.64/ea £0.00
100 mgQM-0136751-06
100 mgQM-0136751-06
£1,029.29/ea		 £0.00
£1,029.29/ea £0.00
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VU0422288 [CAS 1630936-95-6]

VU0422288 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.