Name: VVD-214 [CAS 3026500-20-6]
Brand: QuantiMol
SKU: QM-0152483-01
Price: 294.22 GBP
Availability: InStock

Product Details

Description
VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase with an IC50 of 0.1316 µM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers[1][2].
CAS Number
[3026500-20-6]
Molecular Formula
C20H21F2N3O4S
Molecular Weight
437.46
Smiles
CS(/C=C/[C@H](C1CC1)NC(C(C(OC2=CC=CC=C2)=N3)=CN=C3C(F)(F)C)=O)(=O)=O
Target
DNA/RNA Synthesis
Concentration
10mM
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Shipping Conditions
Room Temperature

Your cart
Variant	Variant total	Quantity	Price	Variant total
5 mgQM-0152483-01	5 mgQM-0152483-01 £294.22/ea	£0.00	Quantity	£294.22/ea	£0.00

10 mM - 1 mLQM-0152483-02	10 mM - 1 mLQM-0152483-02 £318.51/ea	£0.00	Quantity	£318.51/ea	£0.00

10 mgQM-0152483-03	10 mgQM-0152483-03 £431.51/ea	£0.00	Quantity	£431.51/ea	£0.00

25 mgQM-0152483-04	25 mgQM-0152483-04 £670.87/ea	£0.00	Quantity	£670.87/ea	£0.00

50 mgQM-0152483-05	50 mgQM-0152483-05 £916.29/ea	£0.00	Quantity	£916.29/ea	£0.00

100 mgQM-0152483-06	100 mgQM-0152483-06 £1,267.43/ea	£0.00	Quantity	£1,267.43/ea	£0.00

Total items

£0.00

Product subtotal

Taxes, discounts and shipping calculated at checkout.

VVD-214 [CAS 3026500-20-6]

VVD-214 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.