WAAG-3R

WAAG-3R is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay[1][2]. (Ex/Em = 340/420 nm)

C69H109N23O24

1644.74

O=[N+](C1=CC([N+]([O-])=O)=CC=C1NC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC(C2=C(C=CC=C2)N)=O)[C@@H](C)O)=O)CCC(O)=O)=O)=O)CCC(O)=O)=O)C)=O)CCCNC(N)=N)=O)=O)CO)=O)C(C)C)=O)[C@H](CC)C)=O)C(N[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CCCCN)=O)[O-]

Others

10 mM in DMSO

Room temperature