WB518

WB518 is a potent STAT3 inhibitor. WB518 effectively inhibits STAT3 activation and Keratin 17 expression. WB518 effectively alleviates imiquimod and TPA (HY-18739) -induced animal psoriasis by inhibiting STAT3 phosphorylation and Keratin 17[1].

C20H16BrN5O5S

518.34

COC(C1CN(CC2=C1C(C#N)=C(S2)NC(C3=CN(N=C3)C)=O)C(C4=CC=C(O4)Br)=O)=O

STAT

STAT3

10mM

96.48

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature