Wee1/HDAC-IN-1 [CAS 3037071-29-4]
Wee1/HDAC-IN-1 [CAS 3037071-29-4]
SKU:QM-0015916
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Product Details
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Description
Wee1/HDAC-IN-1 is a dual Wee1/HDAC inhibitor with an IC50 of 1.2 nM for Wee1 and IC50 values of 196 nM for HDAC1, 156 nM for HDAC3, and 55 nM for HDAC6. Wee1/HDAC-IN-1 exhibits strong antiproliferative activity against MV4-11 cells with an IC50 of 0.076 μM. Wee1/HDAC-IN-1 selectively binds to Wee1 and HDACs. Wee1/HDAC-IN-1 interferes with DNA damage repair pathways and induces apoptosis in MV4-11 cells. Wee1/HDAC-IN-1 Wee1/HDAC-IN-1 can be used for the research of acute myeloid leukemia (AML) [1].
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CAS Number
[3037071-29-4]
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Molecular Formula
C33H43N9O4
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Molecular Weight
629.75
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Smiles
O=C1N(N(C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)CCCCCCC(NO)=O)=NC=C21)C5=NC(C(O)(C)C)=CC=C5)CC=C
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Target
Apoptosis; HDAC; Wee1
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Isoform
HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC6; HDAC8
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Shipping Conditions
Room temperature
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Wee1/HDAC-IN-1 [CAS 3037071-29-4]
Wee1/HDAC-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.