WEE1-IN-12 [CAS 3069940-37-7]

WEE1-IN-12 (Compound 87) is a Wee1 kinase inhibitor with an IC50 of 2.0 nM. WEE1-IN-12 can inhibit the proliferation of HT29 cells (IC50: 1.07 μM), and when used in combination with Gemcitabine , the effect is better (IC50: 0.34 μM). WEE1-IN-12 can be used in the research of tumors such as colon cancer[1].

[3069940-37-7]

C38H38Cl2N10O6

801.68

O=C1CCC(C(N1)=O)N2C(C3=CC=CC(NCCCN4CCC(CC4)N5C=C(C=N5)NC6=NC=C(C(OC7CC7)=N6)C(NC8=C(C=CC=C8Cl)Cl)=O)=C3C2=O)=O

Wee1

Room temperature