WK369

WK369 is a novel BCL6 small molecule inhibitor, which exhibits excellent anti-ovarian cancer bioactivity, induces cell cycle arrest and causes apoptosis. WK369 can directly bind to the BCL6-BTB domain and block the interaction between BCL6 and SMRT, leading to the reactivation of p53, ATR and CDKN1A[1].

C19H20FN5O2

369.39

O=C(C=C1)OC2=C1C=C(NC3=NC(N4C[C@H](C)N[C@H](C)C4)=NC=C3F)C=C2

Apoptosis; BCL6

99.89

DMSO : 100 mg/mL (ultrasonic; warming)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature