WL 47 dimer

WL 47 dimer (ligand 1) is a caveolin-1 (CAV-1) ligand with high affinity, selectivity and oligomer dissociation activity. WL 47 dimer simultaneously occupies two binding sites of CAV-1, inducing the dissociation of oligomers. WL 47 dimer has 7500-fold improved affinity compared to its T20 parent ligand and an 80% decrease in sequence length. WL 47 dimer can be used to permit targeted study of CAV-1 function[1].

C80H130N24O18S4

1844.3

O=C([C@@H](N)CSSC[C@H](N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCSC)=O)CC1=CNC2=CC=CC=C12)=O)CO)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCSC)=O)CC3=CNC4=CC=CC=C34)=O)CO

Others

10 mM in DMSO

Room temperature