WNY0824 [CAS 2412707-81-2]

WNY0824 (PLK1/BRD4-IN-1) is an orally active dual inhibitor of PLK1 and BET protein families, with IC50 values ​​of 22, 402.5, 150.7, 103.9, and 311.9 nmol/L for PLK1, BRD2, BRD3, BRD4, and BRDT, respectively. WNY0824 induces cell cycle arrest and apoptosis by inhibiting AR- and MYC-mediated transcriptional processes. In addition, WNY0824 also inhibits tumor growth in Enzalutamide resistant CRPC xenograft tumor models[1][2].

[2412707-81-2]

C31H43N9O2

573.73

O=C(NC1CCN(C)CC1)C2=CC=C(NC(N=C3N(CC4CCCCC4)[C@@H]5CC)=NC=C3N6C5=NN=C6C)C(OC)=C2

Androgen Receptor; Apoptosis; c-Myc; Epigenetic Reader Domain; Polo-like Kinase (PLK)

BRD2; BRD3; BRD4; BRDT; PLK1

10 mM in DMSO

Room temperature