WQ-C-401 [CAS 2376694-72-1]

WQ-C-401 is an orally active platelet-derived growth factor receptor (PDGFR) inhibitor. WQ-C-401 inhibits cell proliferation by blocking PDGFR autophosphorylation in a concentration-dependent manner, with EC50 values of 3.5 nM for PDGFRα Y849 and 5.8 nM for PDGFRβ Y1021. Additionally, WQ-C-401 can inhibit PASMCs proliferation and migration by blocking PDGF-BB-induced ERK1/2 phosphorylation, reducing collagen I synthesis, and increasing α-SMA expression, thereby preventing pulmonary vascular remodeling. WQ-C-401 holds promise for research in the field of pulmonary arterial hypertension[1].

[2376694-72-1]

C24H26N4O3

418.49

CC1=C(OC2CCN(C(C3=CN(C)C=N3)=O)CC2)C=C(NC(C4=CC=CC=C4)=O)C=C1

ERK; PDGFR

PDGFRα; PDGFRβ

99.41

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature